The A-allele of the FTO Gene rs9939609 Polymorphism Is Associated With Decreased Proportion of Slow Oxidative Muscle Fibers and Over-represented in Heavier Athletes

• João Paulo Limongi França Guilherme ; Emiliya S. Egorova ^[1] ; Ekaterina A. Semenova ^[2] ; Elena S. Kostryukova ^[3] ; Nickolay A. Kulemin ^[3] ; Oleg V. Borisov ^[3] ; Sofya A. Khabibova ^[3] ; Andrey K. Larin ^[3] ; Elena A. Ospanova ^[3] ; Alexander V. Pavlenko ^[3] ; Ekaterina V. Lyubaeva ^[4] ; Daniil V. Popov ^[4] ; Evgeny A. Lysenko ^[4] ; Tatiana F. Vepkhvadze ; Egor M. Lednev ; Vadim M. Govorun ; Edward V. Generozov ^[3] ; Ildus I. Ahmetov ; Antonio Herbert Lancha
  1. [1] Kazan State Medical University

     Kazan State Medical University

     Rusia

     
  2. [2] Kazan Federal University

     Kazan Federal University

     Rusia

     
  3. [3] Federal Research and Clinical Centre of Physical-Chemical Medicine, Moscow
  4. [4] Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow

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• Localización: Journal of strength and conditioning research: the research journal of the NSCA, ISSN 1064-8011, Vol. 33, Nº. 3, 2019, págs. 691-700
• Idioma: inglés
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• Resumen

  • The purpose of this study was to explore the frequency of the FTO T > A (rs9939609) polymorphism in elite athletes from 2 cohorts (Brazil and Russia), as well as to find a relationship between FTO genotypes and muscle fiber composition. A total of 677 athletes and 652 nonathletes were evaluated in the Brazilian cohort, whereas a total of 920 athletes and 754 nonathletes were evaluated in the Russian cohort. It was found a trend for a lower frequency of A/A genotype in long-distance athletes compared with nonathletes (odds ratio [OR]: 0.65; p = 0.054). By contrast, it was found an increased frequency of the A-allele in Russian power athletes. The presence of the T/A + A/A genotypes rather than T/T increased the OR of being a Russian power athlete compared with matched nonathletes (OR: 1.45; p = 0.002). Different from that observed in combat sports athletes of lighter weight categories, the A-allele was also over-represented in combat sports athletes of heavier weight categories. The presence of the T/A + A/A genotypes rather than T/T increased the OR of being a combat sports athlete of heavier weight categories compared with nonathletes (OR: 1.79; p = 0.018). Regarding the muscle fibers, we found that carriers of the A/A genotype had less slow-twitch muscle fibers than T-allele carriers (p = 0.029). In conclusion, the A/A genotype of the FTO T > A polymorphism is under-represented in athletes more reliant on a lean phenotype and associated with decreased proportion of slow-twitch muscle fibers, while is over-represented in strength and heavier athletes.