La Dolce Vita of Neurexin: Synaptic Partnerships through Glycosaminoglycans

• Kunimichi Suzuki ^[1] ; Michisuke Yuzaki ^[1]
  1. [1] Keio University

     Keio University

     Japón

     
• Localización: Cell, ISSN 0092-8674, Vol. 174, Nº. 6, 2018, págs. 1337-1338
• Idioma: inglés
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• Resumen

  • Various neurexin transcripts are thought to serve as presynaptic “hub” molecules by binding to their specific synaptic partners. In this issue, Zhang et al. demonstrate that neurexins are heparan sulfate (HS) proteoglycans and that the HS modification is important for synaptic function in vitro and in vivo. These findings open up the possibility of many more binding partners for the neurexins.