Freeing Yeast from Alcohol Addiction (Just) to Make (It) Fat Instead

• Kiran R. Patil ^[2] ; Marcus Ralser ^[1]
  1. [1] Francis Crick Institute

     Francis Crick Institute

     Reino Unido

     
  2. [2] European Molecular Biology Laboratory
• Localización: Cell, ISSN 0092-8674, Vol. 174, Nº. 6, 2018, págs. 1342-1344
• Idioma: inglés
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• Resumen

  • Synthetically re-designing eukaryotic metabolism has proven immensely challenging, raising the question of whether evolution has metabolically hardwired eukaryotic cells. Yu et al. now report that, through orchestrating multiple genetic changes and laboratory evolution, Saccharomyces metabolism can be reprogrammed from its evolutionary objective of producing ethanol to produce large amounts of free fatty acids.