Metabolic Frugality Marks Cancer Cells for Immune Targeting

• Lucas B. Sullivan ^[1]
  1. [1] Fred Hutchinson Cancer Research Center
• Localización: Cell, ISSN 0092-8674, Vol. 174, Nº. 6, 2018, págs. 1344-1346
• Idioma: inglés
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• Resumen

  • Altered cell metabolism is ubiquitous in cancer cells; however, it remains challenging to exploit these alterations for cancer therapy. A new study reveals that metabolic alterations to the urea cycle promote tumor growth but unexpectedly also trigger mutations that mark cancer cells for recognition by immunotherapy.