Chromatin domains go on repeat in disease

• Benoit G. Bruneau ^[1] ; Elphège Nora ^[1]
  1. [1] University of California, San Francisco
• Localización: Cell, ISSN 0092-8674, Vol. 175, Nº. 1, 2018, págs. 38-40
• Idioma: inglés
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• Resumen

  • TAD boundaries are insulators of genomic neighborhoods. In this issue, Sun et al. show that disease-associated tandem repeats are located to TAD boundaries and affect their insulation. The findings have important implications for TAD function and mechanisms underlying diseases such as fragile X syndrome and Huntington’s disease.