Administration of intra-articular hydrogen sulphide reduces the severity of osteoarthritis in vivo

• E.F. Burguera ^[2] ; A. Vela-Anero ^[1] ; T. Hermida-Gomez ^[2] ; P. Filgueira Fernandez ^[2] ; L. Gato-Calvo ^[2] ; C. Vaamonde-García ^[1] ; F.J. Blanco ^[2] ; R. Meijide Failde ^[1]
  1. [1] Universidade da Coruña

     Universidade da Coruña

     A Coruña, España

     
  2. [2] issue Engineering Unit, Rheumatology Research Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
• Localización: Boletín de la Sociedad Española de Hidrología Médica, ISSN 0214-2813, Nº. Extra 1, 2018, págs. 90-91
• Idioma: inglés
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• Resumen

  • Purpose: Osteoarthritis (OA) results in progressive cartilage destruction leading to joint malfunction. Current treatments, mostly symptomatic, are not able to stop or retard the progression of the disease. Hydrogen sulphide is a small gaseous molecule that has shown to prevent cartilage degradation as well as to exert antiinflammatory effects in in vitro models of OA, and is the active component of sulphurous minero-medicinal waters. The purpose here was to evaluate the effects of administering an H2S-producing compound, intra-articularly, in an experimental model of OA.