Resumen de Hydrogen sulphide synthesis is impaired in osteoarthritic chondrocytes from diabetic patients and in vitro in cells exposed to high glucose stress
Carlos Vaamonde García, E.F. Burguera, Francisco J. Blanco García, Rosa Meijide Faílde
Background: A growing number of findings support the hypothesis that type 2 diabetes is an independent risk factor of osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Hydrogen sulfide (H2S) plays an important role in the pathogenesis of diabetes and its complications. In relation, we and other authors have observed a protective impact of H2S induction on activation of pathological pathways in the chondrocyte (1).
