Some challenging pharmaceutical applications performed with state-of-the-art capillary gas chromatography (CGC) are presented. For assay and purity determinations cool on-column (COC) injection is the preferred injection technique. A fast CGC headspace method is described to determine residual solvents in pharmaceutical products. Ethylene oxide and ethylene chlorohydrin, originating from the sterilisation of packaging materials, were measured in pharmaceutical formulations in a fully automated sequence with excellent retention time and peak-area reproducibility.
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