Boosting immunity by targeting post-translational prenylation of small GTPases

• Caroline Robert ^[1] ; Stéphan Vagner ^[1]
  1. [1] University of Paris-Sud

     University of Paris-Sud

     Arrondissement de Palaiseau, Francia

     
• Localización: Cell, ISSN 0092-8674, Vol. 175, Nº. 4, 2018, págs. 901-902
• Idioma: inglés
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• Resumen

  • Diseases leading to immune activation and autoinflammatory phenotypes may provide a reservoir of potentially druggable pathways for optimizing immune adjuvants or boosting antitumor immune responses. Now, Xia et al. report that lipophilic statins or biphosphonates, targeting the mevalonate pathway, act as efficient vaccine adjuvants and synergize with anti-PD1 against cancer.