Peripheral tissue chemokines: homeostatic control of immune surveillance T cells

• Autores: Michelle L. McCully, Ariadni Kouzeli, Bernhard Moser
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 39, Nº. 9, 2018, págs. 734-747
• Idioma: inglés
• Enlaces
  • Texto Completo Ejemplar
• Resumen

  • Cellular immunity is governed by a complex network of migratory cues that enable appropriate immune cell responses in a timely and spatially controlled fashion. This review focuses on the chemokines and their receptors regulating the steady-state localisation of immune cells within healthy peripheral tissues. Steady-state immune cell traffic is not well understood but is thought to involve constitutive (homeostatic) chemokines. The recent discovery of tissue-resident memory T cells (TRM cells) illustrates our need for understanding how chemokines control immune cell mobilisation and/or retention. These studies will be critical to unravel novel pathways for preserving tissue function (aging) and preventing tissue disease (vaccination)