The Serotonin-Dopamine Relationship on the Aggression-Suicidal Risk Axis in Patients with Major Depression Disorder: Describing Some Social Implications

• Raluca Prepelita ^[1] ; Ana-Caterina Cristofor ^[2] ; Romeo Dobrin ^[3] ; Constantin Trus ^[4] ; Alin Ciobica ^[5] ; Roxana Chirita ^[6]
  1. [1] “Grigore T.Popa” University of Medicine and Pharmacy, Iasi, ROMANIA. E-mail: raluca.prepelita@yahoo.com
  2. [2] “Grigore T.Popa” University of Medicine and Pharmacy, Iasi, ROMANIA. E-mail: ina_cristofor@yahoo.com
  3. [3] “Grigore T.Popa” University of Medicine and Pharmacy, Iasi, ROMANIA. E-mail: romeodobrin2002@gmail.com (Corresponding Author)
  4. [4] Dunarea de Jos University, Department of Morphological and Functional Sciences, Faculty of Medicine, Galati, ROMANIA. E-mail: dilconstantin@yahoo.com
  5. [5] Alexandru Ioan Cuza University, Department of Research, Faculty of Biology, Iasi, ROMANIA; Academy of Romanian Scientists, Bucaresti, ROMANIA; Center of Biomedical REsearch, Romanian Academy, Iasi, ROMANIA. e-mail: alin.ciobica@uaic.ro
  6. [6] “Grigore T.Popa” University of Medicine and Pharmacy, Iasi, ROMANIA. E-mail: d.stigma@gmail.com

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• Localización: Revista de Cercetare si Interventie Sociala, ISSN-e 1584-5397, Vol. 65, 2019, págs. 111-130
• Idioma: inglés
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• Resumen

  • In the present report we want it to see if there is a connection between serotonin and/or dopamine and the aggression-suicidal risk axis in patients with major depression disorders. 113 patients were selected and we used the following specific scales: Hamilton Depression Rating Scale, the Colombia Suicide Risk Scale, and the Buss & Perry Aggression Questionnaire. Serotonin and dopamine were determined by high pressure liquid chromatography. The results of this study are clear in terms of the relationship between neurotransmitters serotonin and dopamine on one hand and aggression and suicide risk on the other. Our analysis of the data reveals significant Pearson correlations with both aggressive serotonin and dopamine and suicide risk. Moreover, following linear regression, both serotonin levels and dopamine levels resulted in significant predictors of aggression and suicide risk. In addition, the social implications of our results are presented and discussed.