Timothy J. Welsh, Yi Shen, Aviad Levin, Tuomas P. J. Knowles
The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et al., 2018 , Shin et al., 2018 ). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.
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