Low percentages of regulatory T cells in common variable immunodeficiency (CVID) patients with autoimmune diseases and its association with increased numbers of CD4+CD45RO+ T and CD21low B cells

Gabriela  López Herrera; Laura Berrón Ruiz; Nora Hilda Segura  Méndez; P. O’Farril-Romanillos; M.E. Nuñez Nuñez; María del Carmen Zárate Hernández; D. Mojica Martínez; Marco Antonio Yamazaki-Nakashimada; Aide Tamara Staines Boone; L. Santos Argumedo

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Low percentages of regulatory T cells in common variable immunodeficiency (CVID) patients with autoimmune diseases and its association with increased numbers of CD4+CD45RO+ T and CD21low B cells

G. López-Herrera ^[4] ; L. Berrón-Ruiz ^[4] ; N.H. Segura-Méndez ^[1] ; P. OFarril-Romanillos ^[1] ; M.E. Nuñez-Nuñez ^[2] ; M.C. Zarate-Hernández ^[3] ; D. Mogica-Martínez ^[5] ; M.A. Yamazaki-Nakashimada ^[4] ; A.T Staines-Boone ^[6] ; L. Santos-Argumedo ^[7]
1. [1] Hospital de Especialidades
  
  Hospital de Especialidades
  
  México
2. [2] Hospital Civil de Guadalajara
  
  Hospital Civil de Guadalajara
  
  México
3. [3] Hospital Universitario Dr José Eleuterio Gonzalez
  
  Hospital Universitario Dr José Eleuterio Gonzalez
  
  México
4. [4] Instituto Nacional de Pediatría SSA, Ciudad de México, Mexico
5. [5] Centro Médico “La Raza”, IMSS, Ciudad de México, Mexico
6. [6] Centro Médico Noreste IMSS, Monterrey, Nuevo León, Mexico
7. [7] CINVESTAV IPN, Ciudad de México, Mexico
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Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 47, Nº. 5, 2019, págs. 457-466
Idioma: inglés
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Resumen
- Background Common variable immunodeficiency (CVID) is a heterogeneous group of primary antibody deficiencies defined by marked reductions in serum IgG, IgA and/or IgM levels and recurrent bacterial infections. Some patients are associated with defects in T cells and regulatory T cells (Tregs), resulting in recurrent viral infections and early-onset autoimmune disease.
  
  Methods We analyzed whether there is an association between Tregs cells (CD4+CD25+CD127low and CD4+CD25+FoxP3+); memory T cells (CD4+CD45RO+); memory B cells (CD19+CD27-IgD-); and CD21low B cells (CD19+CD38lowCD21low); as well as autoimmune manifestations in 36 patients with CVID (25 women and 11 men, mean age 24 years), all by flow cytometry.
  
  Results Fourteen patients presented with autoimmune diseases (AI) (39%), including 11 with autoimmune thrombocytopenia (ITP) (31%); two with vitiligo (6%); one with systemic lupus erythematosus (LES) (3%); and one with multiple sclerosis (MS) (3%). CVID patients with AI had a reduced proportion of Tregs (both CD4+CD25+CD127low and FoxP3+ cells) compared with healthy controls. CVID patients with AI had expanded CD21low B cell populations compared with patients who did not have AI. A correlation between increased CD4+CD45RO T cell populations and reduced Tregs was also observed.
  
  Conclusions Our results showed that 39% of patients with CVID had AI and reduced Tregs populations. Research in this area might provide noteworthy data to better understand immune dysfunction and dysregulation related to CVID.