Mechanistic insights into autoimmune pancreatitis and igg4-related disease

• Autores: Tomohiro Watanabe, Kosuke Minaga, Ken Kamata, Masatoshi Kudo, Warren Strober
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 39, Nº. 11, 2018, págs. 874-889
• Idioma: inglés
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• Resumen

  • Autoimmune pancreatitis (AIP) is a pancreatic manifestation of a recently defined disease form known as IgG4-related disease (AIP/IgG4-RD). AIP/IgG4-RD is characterized by elevated systemic IgG4 antibody concentrations and lesional tissues infiltrated by IgG4-expressing plasmacytes. In addition, recent studies have revealed that, in common with other autoimmune diseases, such as systemic lupus erythematosus (SLE) and psoriasis, AIP/IgG4-RD is associated with increased type I IFN (IFN-I) production by plasmacytoid dendritic cells (pDCs). However, unlike SLE, AIP/IgG4-RD is characterized by elevated IFN-I-dependent IL-33 production, the latter emerging as an important contributor to inflammation and fibrotic responses characterizing this disease. On this basis, we propose that blockade of the IFN-I/IL-33 axis might constitute a successful approach to treating this unique type of autoimmunity