Mechanisms of HLA-DP Antigen Processing and Presentation Revisited

• Autores: Mark Anczurowski, Naoto Hirano
• Localización: Trends in immunology, ISSN 1471-4906, Vol. 39, Nº. 12, 2018, págs. 960-964
• Idioma: inglés
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• Resumen

  • Polymorphisms in HLA-DP can modulate interactions with the invariant chain chaperone, contributing independently to differences in the peptide repertoire presented on DP. The resulting presentation of intracellular antigens directly to CD4+ T cells may partly explain genetic and clinical studies describing previously unexplained links between polymorphism in DP and disease