4F‐MDMB‐BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework

• Krotulski, Alex J. ; Mohr, Amanda L.A. ^[1] ; Kacinko, Sherri L. ^[2] ; Fogarty, Melissa F. ^[3] ; Shuda, Sarah A. ^[3] ; Diamond, Francis X. ^[3] ; Kinney, William A. ^[4] ; Menendez, M.J. ^[5] ; Logan, Barry K. ^[3]
  1. [1] Center for Forensic Science Research and Education (CFSRE), Fredric Rieders Family Foundation. Estados Unidos.
  2. [2] NMS Labs, 200 Welsh Road, Horsham,Estados Unidos
  3. [3] edric Rieders Family Foundation. Estados Unidos
  4. [4] IteraMed Consulting LLC. Estados Unidos.
  5. [5] Organized Crime Drug Enforcement Task Force (OCDETF), U.S. Department of Justice.Estados Unidos

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• Localización: Journal of forensic sciences, ISSN-e 1556-4029, ISSN 0022-1198, Vol. 64, Nº. 5, 2019, págs. 1451-1461
• Idioma: inglés
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• Resumen

  • This is the first report regarding the characterization of the new synthetic cannabinoid 4F-MDMB-BINACA. 4F-MDMB-BINACA was first analytically confirmed in seized drug material using gas chromatography–mass spectrometry (GC-MS), liquid chromatography–quadrupole time-of-flight mass spectrometry (LC-QTOF), and nuclear magnetic resonance (NMR) spectroscopy. Subsequent to this characteriza-tion, 4F-MDMB-BINACA was detected in biological specimens collected as part of forensically relevant casework, including medicolegal deathinvestigations and drug impaired driving investigations, from a variety of regions in the United States. Further analysis of biological specimensresulted in the identification of the metabolites 4F-MDMB-BINACA 3,3-dimethylbutanoic acid and 4-OH-MDMB-BINACA. 4F-MDMB-BINACA is appearing with increasing frequency as a contributory factor in deaths, creating morbidity and mortality risks for drug users. Laborato-ries must be aware of its presence and impact, incorporating 4F-MDMB-BINACA into workflows for detection and confirmation.