Effectiveness and safety of Omalizumab in the treatment of chronic spontaneous urticaria: Systematic review and meta-analysis

• N.P.M. Rubini ^[1] ; L.F.C. Ensina ^[2] ; E.M.K. Silva ^[3] ; F. Sano ^[4] ; D. Solé ^[5]
  1. [1] Universidade Federal do Estado do Rio de Janeiro

     Universidade Federal do Estado do Rio de Janeiro

     Brasil

     
  2. [2] Universidade Federal de São Paulo

     Universidade Federal de São Paulo

     Brasil

     
  3. [3] Division of Emergency and Evidence Based Medicine, EPM-UNIFESP and Researcher of Cochrane Center of Brazil
  4. [4] Nipo-Brazilian Hospital, São Paulo
  5. [5] Clinical Immunology and Rheumatology, Department of Pediatrics, EPM-UNIFESP, São Paulo

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 47, Nº. 6, 2019, págs. 515-522
• Idioma: inglés
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• Resumen

  • Introduction Chronic spontaneous urticaria (CSU) affects approximately 1% of the population, affecting both children and adults. Omalizumab (Oma) is a therapeutic option for patients with refractory forms of CSU.

    Objectives To determine the effectiveness and safety of Oma in the treatment of CSU.

    Methods Systematic review (Cochrane Collaboration methodology) of randomized clinical trials comparing Oma to placebo in refractory CSU treatment. The search is based on MEDLINE; EMBASE, Central Cochrane Library, and LILACS. The outcomes evaluated were: control of the illness, adverse events, and quality of life.

    Results Of the 848 identified studies 13 were selected for further review and six were included in the meta-analysis. For all outcomes, high-quality evidence has confirmed that Oma is effective in the treatment of CSU. The dosage of 300mg/month achieved better results; namely a significant reduction in pruritus, papules, and urticaria activity, as well as an increase in the number of patients with a controlled condition, improvement in the quality of life and no differences in adverse events compared to the placebo.

    Conclusions High-quality evidence demonstrates that Oma is effective and safe in the treatment of CSU refractory to therapy with H1 antihistamines.