Identification of two novel single nucleotide polymorphism sites in the Myostatin (MSTN) gene and their association with carcass traits in meat-type rabbits (Oryctolagus cuniculus)

• Autores: L. Q. Yang, K. Zhang, Q. Y. Wu, J. Li, S. J. Lai, T. Z. Song, M. Zhang
• Localización: World Rabbit Science, ISSN-e 1989-8886, ISSN 1257-5011, Vol. 27, Nº. 4, 2019, págs. 249-256
• Idioma: inglés
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• Resumen

  • Two unknown single nucleotide polymorphism (SNP) sites in exons 1 (c.194C>T) and 2 (c.445T>A) of meat-type rabbit MSTN gene were identified in the study. Our objective was to analyse the population genetics structure of the two novel SNP sites in 230 individuals from six breeds and their associations with carcass traits of rabbits. We found that live body weight (BW), cold carcass weight (CCW), reference carcass weight (RCW), CCW percentage (PCCW) and RCW percentage (PRCW) of the rabbits with the genotype CC at the c.194C>T of exon 1 or AA at the c.445T>A of exon 2 were significantly higher than those with other genotypes. Diplotype significantly affected BW, RCW, CCW, PRCW (P<0.01) and PCCW and PCM (P<0.05). CC/AA was the advantageous diplotype for BW, RCW, CCW and PCM, and TT/AA was the advantageous diplotype for PCCW and PRCW. In contrast, TT/TT was the negative diplotype for BW, CCW, RCW, PCCW and PRCW, and TT/AA was the negative diplotype for PCM. The results suggest that the two new mutations of MSTN gene significantly affected BW, CCW, RCW, PCCW and PRCW of rabbits, and MSTN may be an important candidate gene of carcass traits in meat-type rabbits.