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The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis

    1. [1] University of Hamburg

      University of Hamburg

      Hamburg, Freie und Hansestadt, Alemania

    2. [2] Max Planck Institute for Plant Breeding Research

      Max Planck Institute for Plant Breeding Research

      Kreisfreie Stadt Köln, Alemania

    3. [3] University of Paris-Saclay

      University of Paris-Saclay

      Arrondissement de Palaiseau, Francia

    4. [4] University of Vienna

      University of Vienna

      Innere Stadt, Austria

    5. [5] 2 RIKEN Center for Sustainable Resource Science Yokohama Japan; 8Present address: Solution Research Laboratory AS ONE Corporation Kawasakiku, Kawasaki Japan
  • Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 39, Nº. 3, 2020
  • Idioma: inglés
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  • Resumen
    • Meiosis is key to sexual reproduction and genetic diversity. Here, we show that the Arabidopsis cyclin‐dependent kinase Cdk1/Cdk2 homolog CDKA;1 is an important regulator of meiosis needed for several aspects of meiosis such as chromosome synapsis. We identify the chromosome axis protein ASYNAPTIC 1 (ASY1), the Arabidopsis homolog of Hop1 (homolog pairing 1), essential for synaptonemal complex formation, as a target of CDKA;1. The phosphorylation of ASY1 is required for its recruitment to the chromosome axis via ASYNAPTIC 3 (ASY3), the Arabidopsis reductional division 1 (Red1) homolog, counteracting the disassembly activity of the AAA + ATPase PACHYTENE CHECKPOINT 2 (PCH2). Furthermore, we have identified the closure motif in ASY1, typical for HORMA domain proteins, and provide evidence that the phosphorylation of ASY1 regulates the putative self‐polymerization of ASY1 along the chromosome axis. Hence, the phosphorylation of ASY1 by CDKA;1 appears to be a two‐pronged mechanism to initiate chromosome axis formation in meiosis.


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