A new and simple scoring system to predict overall survival after irradiation for metastatic spinal cord compression

• P. Nenclares ^[2] ; S. Guardado ^[1] ; L. Asiáin ^[1] ; M. Á. Pérez-Escutia ^[1] ; M. C. Peña ^[1] ; A. Bartolomé ^[1] ; A. Ruíz ^[1] ; M. Á. Cabeza ^[1] ; M. Colmenero ^[1] ; N. Gascón ^[1] ; V. Rodríguez ^[1] ; R. Prados ^[1] ; R. D´Ambrosi ^[1] ; J. F. Pérez-Regadera ^[1]
  1. [1] Hospital Universitario 12 de Octubre

     Hospital Universitario 12 de Octubre

     Madrid, España

     
  2. [2] Royal Marsden NHS Trust Foundation, Reino Unido
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 22, Nº. 3 (March), 2020, págs. 440-444
• Idioma: inglés
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• Resumen

  • Purpose To develop a model that predicts survival in patients irradiated for metastatic spinal cord compression (MSCC), hence assisting in the decision between a short and a long-course radiotherapy (RT) regimen.

    Methods 138 patients diagnosed with MSCC and treated with RT alone were included. Based on a multivariate analysis, a scoring system was developed. It included four prognostic variables: age, number of vertebrae, ECOG and histology. Total scores ranged between 14 and 24 points and patients were divided into two groups.

    Results The 6-month survival rate was 22% for patients with a score of 14–18 points; and 69% for patients with a score of 19–24 points (P < 0.001). The system exhibits a high specificity and positive predictive value and an appropriate discriminative ability.

    Conclusions Patients with scores between 19 and 24 points were found to survive longer, thus a long-course RT appears to be more appropriate.