A transient hyperammonemia in a neonatal patient due to a toxic dose with valproic acid

• Autores: Felix Gómez de Rueda, María Eugenia Tena Sempere, Myriam Cardenas Anton, Tiscar Navarro Dueñas, Marta Hernández Hernández, Jesús de la Cruz Moreno
• Localización: European journal of clinical pharmacy: atención farmacéutica, ISSN 2385-409X, Vol. 21, Nº. 4, 2019, págs. 227-229
• Idioma: inglés
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• Resumen

  • The hyperammonemias secondary to the use of valproic acid are known, although fortunately infrequent. Despite the fact that in the current treatment of seizures, other drugs are the most commonly used (phenobarbital, levetirazetam or ox-carbazepine), valproic acid remains a classic alternative to reverse the seizures refractory to other treatments. The high dosage of valproic acid, often required to control seizures, can lead to transient hyperammonemia, which if not treated quickly, could lead to hyperammonemic encephalopathy capable of damaging the central nervous system, especially in the pediatric population due to state of development of this one. © 2019 Rasgo Editorial S.A.. All rights reserved.