Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via P53/P21 pathway

• G. Li ^[1] ; R. Zhang ^[1] ; X. Zhang ^[1] ; S. Shao ^[1] ; F. Hu ^[1] ; Y. Feng ^[1]
  1. [1] Huazhong University of Science and Technology

     Huazhong University of Science and Technology

     China

     
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 22, Nº. 4, 2020, págs. 503-511
• Idioma: inglés
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• Resumen

  • Purpose The purpose of this study was to evaluate effect of MSCs on CRC cell.

    Methods in this study the MSC was isolated from CRC tissue, its effect on CRC cells was investigated in vivo and vitro, and the underlying mechanism was investigated.

    Results In this study we found that MSC-CM could promote colorectal cancer cells escape from senescence both in vitro and in vivo. Further research we demonstrated that MSC-CM acted in colorectal cancer cells senescence through P53/P21 pathway. Next we found that MSC-CM regulate P53 via posttranscription method.

    Conclusion Collectively, these results reveal that MSCs can help colorectal cancer cells defend against senescence through P53/P21 pathway, which may be a new strategy for colorectal cancer therapy.