Management of BK Polyomavirus Infection in Kidney and Kidney-Pancreas Transplant Recipients: A Review Article

• Autores: Nissreen Elfadawy, Masaaki Yamada, Nagaraju Sarabu
• Localización: Infectious disease clinics of North America, ISSN 0891-5520, Vol. 32, Nº. 3, 2018 (Ejemplar dedicado a: Management of Infections in Solid Organ Transplant Recipients), págs. 599-613
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • BK virus (BKV) can cause graft dysfunction or failure in kidney transplant recipients and hemorrhagic cystitis in allogeneic hematopoietic stem cell transplant patients. BKV-associated nephropathy (BKVAN) emerged as a common complication in the late 1990s, probably due to the introduction of potent immunosuppressive agents. BKVAN occurred in up to 5% of kidney transplant recipients, with graft failure in up to 70%. Since universal implementation of effective screening and treatment strategies, BKV is no longer a common cause of graft failure; reported graft loss is only 0% to 5%. This article briefly describes BK virology, epidemiology, diagnosis, and management.