Alendronate effect in esophagus, stomach and liver: An animal based pathological study

• Theodora Papamitsou ^[1] ; Sotiris Sotiriou ^[1] ; Apostolos Papakoulas ^[1] ; Alexandros Toskas ^[1] ; Dimitrios Kamperis ^[1] ; Sofia Karachrysafi ^[1] ; Eva-Maria Dietrich ^[1] ; Stergios Lialiaris ^[2] ; Antonia Sioga ^[1]
  1. [1] Aristotle University of Thessaloniki

     Aristotle University of Thessaloniki

     Dimos Thessaloniki, Grecia

     
  2. [2] Democritus University of Thrace

     Democritus University of Thrace

     Dimos Komotini, Grecia

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 35, Nº. 4, 2020, págs. 417-422
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Bisphosphonates are commonly used in clinical practice. Their effectiveness is indisputable, however their adverse effects, especially in the GI tract, are still controversial. In our report, we demonstrate pathological findings of the effect of systematic alendronate administration in esophagus, stomach and the liver of an in vivo animal model of 15 Wistar rats.

    Light microscopy with immunohistochemistry and electron microscopy were used. Microscopic findings of inflammation of the stomach and mild hepatic dysfunction were observed. Conclusively, alendronate can potentially affect gastric mucosa and liver function on this animal experimental model.