Roles of integrins in fibronectin matrix assembly

• Wu, C. ^[1]
  1. [1] Department of Biochemistry and Molecular Biology, Samuel C. Johnson Medical Research Center, Mayo Clinic Scottsdale, 13400 E. Shea Blvd, Scottsdale, USA
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 12, Nº. 1, 1997, págs. 233-240
• Idioma: inglés
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• Resumen

  • Fibro nec tin (Fn ) ma trix asse mb ly is a dynamic cellular process in whi ch the soluble dimeric Fn molecules are assembled into insoluble, d isulfide bond stabilized fi brill ar polymeric matrix . Fn matrix assembly req uires s pec ific Fn binding integrin s . Seve ra l Fn binding integrins that are capable of mediating Fn matrix assembl y have bee n ident ified . They include a5B I , a ll bB3 and avB3 integrins. Cells regul a te the matri x assembly process no t o nl y by controlling cell surface expression level of the Fn binding integrins but also by mo dul a tin g F n bindin g a nd cy tos ke le to n b indin g ac ti vities of the integrins. A majo r cha lle nge of future studies is to de lineate the signa l transductio n pathway that regulates Fn matrix assembly.