Ultrastructure of atheromatous lesions experimentally induced in Syrian hamster of the APA strain

• Yamanouchi, J. ^[1] ; Sugawara, Y. ^[2] ; Itagaki, S. ^[1] ; Doi, K. ^[1]
  1. [1] University of Tokyo

     University of Tokyo

     Japón

     
  2. [2] Toxicology Laboratory, Basic Research Laboratories, Toray Industries, Inc., Otsui-shi, Shiga, Japan
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 12, Nº. 2, 1997, págs. 433-438
• Idioma: inglés
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• Resumen

  • In order to examine whether diabetes enhances primary aortic lesions up to atherosclerotic ones, mild primary lesions were induced in aorta of APA hamsters by an administration of vitamin O2 (YO) and/or stop-and-reflow (SR)-operation, a modification of renal artery clamping. At 2 months after the treatment with the combination of YO-administration and SRoperation, atheromatous lesions, characterized by an appearance of many foam cells in the intima, were observed in the abdominal aorta, the site of SRoperation, in streptozotocin (SZ)-induced diabetic AP A hamsters. Foam cells in the atheromatous lesions were originated from smooth muscle cells and monocyte/ macrophages. On the other hand, neither YOadministration alone nor SR-operation alone developed atheromatous lesions in SZ-induced diabetic APA hamsters. In conclusion, we succeeded in a rapid induction of atherosclerotic lesions in abdominal aorta of SZ-induced diabetic APA hamsters by the combination of YO-administration and SR-operation.