Lipid signaling and cell responses at the nuclear level

• L. M. Neri ^[1] ; S. Capitani ^[1] ; P. Borgatti ^[1] ; A. M. Martelli ^[2]
  1. [1] University of Ferrara

     University of Ferrara

     Ferrara, Italia

     
  2. [2] University of Trieste

     University of Trieste

     Trieste, Italia

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 14, Nº. 1, 1999, págs. 321-335
• Idioma: inglés
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• Resumen

  • The nucleus is known to be a site for an active lipid metabolism. Although phospholipids are present in the nuclear envelope, evidence suggests that they are also located further inside the nucleus. The function of these intranuclear lipids has escaped clarification for many years. Early experiments showed that they can interact with DNA double helix affecting its thermal stability and can influence RNA synthesis in isolated nuclei. However, in the last 10 years several investigations have suggested that they may be involved in signal transduction pathways at the nuclear level and a growing body of evidence supports this hypothesis.