Resumen de Antinuclear antibody-keratinocyte interactions in photosensitive cutaneous lupus erythematosus
Autoimmune diseases are characterized by va rious circul ating autoantibodies, especiall y antinuclear ant ibod ies (ANA). II has been a long-standing issue as to whether and/or how ANA interact with epidermal cells to produce skin lesions. Of these ANA, the anti-SS-A/Ro anti body is th e most close ly assoc iated with photosensitivity in patients with systemic lupus erythematosus (SLE) and its subgroups, including subacute cutaneous lu pus e ryth ema tosus (SC LE) and neo nata l lupu s erythematosus (N LE). SS-A/Ro antigens are present in the nucleus and cytoplasm, and interestingly, ultrav iolet B (UVB) light tra nslocates these antigens to the surface of th e c ultured ke ratin ocy tes. Thu s. anti -SS-A/Ro antibodies in the sera can bind to the relevant antigens expressed on the UVB-irradiated keratinocy te surface, and have been speculated to be an important inducer of antibody-dependent ke ratinocyte damage. This interaction be tween the anti-SS-A/Ro antibodi es and UVBirrad iated keratin ocy tes may induce th e skin lesions through a cy totox ic mechanism. This review will foc us on the involvement of antibody-depe ndent ce llular cy totox icity in the pathogenesis of the skin lesions observed in photosensitive cut aneous lupus erythematosus.
