Serotonin immunoreactivity in the carotid body of adult humans

• Habec, J. ^[1] ; Pallot, D.J. ^[2] ; Kummer, W. ^[3]
  1. [1] Institute of Pathology Celle

     Institute of Pathology Celle

     Landkreis Celle, Alemania

     
  2. [2] United Arab Emirates University

     United Arab Emirates University

     Emiratos Árabes Unidos

     
  3. [3] Department of Anatomy and Cell Biology, PhilippsUniversity, Marburg, Germany

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 9, Nº. 2, 1994, págs. 227-232
• Idioma: inglés
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  • The distribution of serotonin immunoreactivity (-1R) was studied in adult human carotid bodies, obtained at post-mortem, using both the peroxidaseantiperoxidase method on paraffin sections and a doublelabelling immunofluorescence on frozen sections.

    Antibodies against synaptophysin and protein gene product (PGP) 9.5 were used for identification of serotonin-1R cells. Serotonin-1R was demonstrable in the carotid bodies of adult humans and it was coexpressed mostly with synaptophysin or PGP 9.5 in type 1 cells.

    Some serotonin immunopositive type I cells were located in close proximity to capillaries. Serotonin-IR was also observed in a few endothelial cells.