Androgen status and expression of glycoconjugates and lectins in the epithelial cells of the mouse ventral prostate. A glycohistochemical approach

• Akif, F. ^[1] ; Gabius, H.J. ^[2] ; Danguy, A. ^[1]
  1. [1] Université Libre de Bruxelles

     Université Libre de Bruxelles

     Arrondissement Brussel-Hoofdstad, Bélgica

     
  2. [2] Ludwig Maximilian University of Munich

     Ludwig Maximilian University of Munich

     Kreisfreie Stadt München, Alemania

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 9, Nº. 4, 1994, págs. 705-713
• Idioma: inglés
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• Resumen

  • We investigated histochemically the expression of glycans and endogenous sugar-binding proteins (endolectins) in the ventral prostate of normal and androgen-deprived mice. The avidin-biotinperoxidase complex technique was used with a panel of biotinylated lectins and neoglycoproteins, respectively, on paraffin sections. Characteristic binding patterns depending upon the type of lectin were observed in the glandular epithelium and basement membranes. This report also initiates the histochemical study of endogenous glycan-binding proteins in this maleaccessory sex organ. Remarkably, the endocrine status was found to affect the distribution of lectin-reactive determinants of glycoconjugates as well as endolectins. The histophysiological significance of these modifications in the glandular cells are discussed in the light of previous biochemical findings obtained mainly in humans and the rat.