The effects of long-term low-protein intake on gastrin cells of the rat antral mucosa during adulthood

• Varagic, J. ^[1] ; Koko, V. ^[1] ; Todorovic, V. ^[2] ; Bozovic, Z. ^[3] ; Lackovic, V. ^[4] ; Vuzevski, V.D. ^[5]
  1. [1] Institute for Medical Research,, Belgrade, Yugoslavia
  2. [2] Institute for Medical Research,e, Belgrade, Yugoslavia
  3. [3] Center for Multidisciplinary Study, Belgrade, Yugoslavia
  4. [4] Faculty of Medicine, Belgrade, Yugoslavia
  5. [5] Department of Pathology, Erasmus Universteit Rotterdam, Rotterdam, The Netherlands

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 11, Nº. 4, 1996, págs. 837-843
• Idioma: inglés
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  • The effect of experimental protein malnutrition on gastrin producing cells in the antral part of the stomach was studied in male Wistar rats. Isoenergetic diets containing 25% (C-25) or 6% (PD-6) were given in isocaloric amounts during a 4-month experiment. All rats were offered drinking water ad libitum. The results showed that the long-term protein diet did not produce changes in the gastrin cell number. At the ultrastructural level G cells exhibited a decreased size of the nucleus. They were found to have an increased total granule volume density but the volume density of dense-cored granules was lower. The serum gastrin levels were significantly lowered by feeding the low protein diet. These changes are compatible with decreased functional activity of G cells under long-term protein deprivation.