Predicting the outcome of respiratory disease in wheezing infants using tidal flow-volume loop shape

E. Keklikian; Paul Cornes; Camilo José Cela Conde; M. Sánchez Solís; Luis Vicente García-Marcos Álvarez; J. A. Castro Rodríguez

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Predicting the outcome of respiratory disease in wheezing infants using tidal flow-volume loop shape

E. Keklikian ^[1] ; P. Cornes ^[2] ; C.J. Cela ^[1] ; M. Sanchez Solis ^[4] ; L. García Marcos ^[4] ; J.A. Castro-Rodriguez ^[3]
1. [1] Centro Medico Teknon
  
  Centro Medico Teknon
  
  Barcelona, España
2. [2] Universidad Favaloro
  
  Universidad Favaloro
  
  Argentina
3. [3] Pontificia Universidad Católica de Chile
  
  Pontificia Universidad Católica de Chile
  
  Santiago, Chile
4. [4] Paediatric Pulmonology Unit, Virgen de la Arrixaca University Children’s Hospital, Murcia, Spain
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Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 48, Nº. 4, 2020, págs. 355-359
Idioma: inglés
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Resumen
- Introduction and objectives Wheezing (RW) infants with a positive asthma predictive index (API+) have a lower lung function as measured by forced expiratory techniques. Tidal flow-volume loops (TFVL) are easy to perform in infants, and sedation is not necessary.
  
  Materials and methods A total of 216 wheezing infants were successfully measured, and 183 of them were followed for over a year. TFVL loops were classified into one of three categories depending of their geometric shape (symmetric, convex, and concave). Respiratory rate (Rr), presence of API+, and the number of exacerbations during the following year were also recorded.
  
  Results Children with concave loops had more exacerbations in the following year (OR = 6.8 [IC95% 3.33;13.91]). Infants API + were also significantly more related to concave loops (OR = 10.02 [IC 95% 4.53; 22.15]). Rr was higher in infants with concave loops (44+/−15.5 vs. 36.6 +/−12.6; p < 0.01).
  
  Conclusion Infants with a concave TFVL have a higher probability of experiencing exacerbations in the following year, and are at a higher risk of suffering asthma.