Interleukin 10:: the critical role of a pleiotropic cytokine in food allergy
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Natalia Nedelkopoulou [1] ; Anil Dhawan [3] ; Ioannis Xinias [1] ; Dimos Gidaris [2] ; Evangelia Farmaki [1]
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[1] Aristotle University of Thessaloniki
Aristotle University of Thessaloniki
Dimos Thessaloniki, Grecia
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[2] University of Nicosia
University of Nicosia
Chipre
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[3] King’s College Hospital NHS Foundation Trust and MowatLabs, London, UK
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- Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 48, Nº. 4, 2020, págs. 401-408
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Despite advances in research, the pathophysiology of food allergy has not yet been fully elucidated. IL-10 has both a pro- and anti-inflammatory effect on the development of food allergy and in order to understand its different immune-modulatory effects the factors that influence the inflammatory microenvironment need to be taken into account. Specific single nucleotide polymorphisms of the IL-10 gene seem to confer an increased risk of developing food allergy, but to date there is a substantial lack of genome- wide association studies regarding the genetic and epigenetic underpinnings of the disease. Special interest has been drawn to the development of allergen-specific regulatory CD4+CD25+ T-cells secreting IL-10 in the immunotherapy of allergic diseases. In addition, a distinct population of human tolerogenic dendritic cells (DC), DC-10 seems to hold great potential and could potentially serve as a therapeutic tool to improve the management of food allergy.
