A Visual Organic Chemistry Reaction: The Synthesis of 4-Amino-3-nitrobenzoic Acid Methyl Ester via Fischer Esterification

• Caleb M. T. Kam ^[1] ; Stephan M. Levonis ^[1] ; Stephanie S. Schweiker ^[1]
  1. [1] Bond University

     Bond University

     Australia

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 97, Nº 7, 2020, págs. 1997-2000
• Idioma: inglés
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• Resumen

  • The synthesis of 4-amino-3-nitrobenzoic acid methyl ester is a simple Fischer esterification reaction designed as an experiment for use in an introductory organic chemistry course. The compound was synthesized as a one-pot reaction within 30 min to 16 h, with 1 h producing a workable yield. The bright-yellow solid was purified using liquid–liquid extraction, and the extraction process was monitored by a marked color change. The product was then characterized by 1H and 13C NMR spectroscopy and thin-layer chromatography.