Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis

• A. Mamoune ^[1] ; V. Durand ^[1] ; P. Le Goff ^[1] ; Y.-L. Pennec ^[1] ; P. Youinou ^[1] ; R. Le Corre ^[1]
  1. [1] Brest University Medical School, Brest, France
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 15, Nº. 2, 2000, págs. 587-591
• Idioma: inglés
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• Resumen

  • CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within the CD45RB+ compartment, there appears to be more of the fully-differentiated than of the early-differentiated CD4+ T cells. In spite of the fact that these lymphocytes are close to undergoing apoptosis, this programmed cell death is inhibited in the rheumatoid synovium.