Cell proliferation in the developing rat pineal gland. A bromodeoxyuridine immunohistochemical study

• Calvo, J.L. ^[1] ; Boya, J. ^[1] ; Carbonell, A.L. ^[1] ; García-Mauriño, J.E. ^[1]
  1. [1] Universidad Complutense de Madrid

     Universidad Complutense de Madrid

     Madrid, España

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 15, Nº. 4, 2000, págs. 1005-1010
• Idioma: inglés
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• Resumen

  • The immunohistochemical detection of bromodeoxyuridine (BrdU) was used to study the cell proliferation in the developing rat pineal gland, from the appearance of pineal primordium in the embryonic day IS (E1S) until 30 days after birth. The results showed three different proliferative phases. From E1S to E21, the pineal gland shows a phase of rapid proliferation.

    The second phase corresponds to the first postnatal week, in which the number of labeled cells per surface unit decreases suddenly to values between 20% to 10% of those of embryonic period. From the second postnatal week onwards, the number of BrdU-positive cells progressively decreases.