Inhibited differentiation of Langerhans cells in the rat epidermis upon systemic treatment with cyclosporin A

• Borghi-Cirri, M.B. ^[1] ; Riccardi-Arbi, R. ^[1] ; Bacci, S. ^[1] ; Mori, M. ^[1] ; Pimpinelli, N. ^[1] ; Romagnoli, P. ^[1] ; Filipponi, F. ^[2]
  1. [1] University of Florence

     University of Florence

     Firenze, Italia

     
  2. [2] University of Pisa

     University of Pisa

     Pisa, Italia

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 16, Nº. 1, 2001, págs. 107-112
• Idioma: inglés
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• Resumen

  • The immunosuppressant drug cyclosporin A (CsA) is known to cause reduction in number, DNA synthesis and function of Langerhans cells (LC). Since also the differentiation of LC is known to be hampered in conditions of acquired immunodeficiency not due to drugs, we investigated whether this occurs with CsA.

    Rats were injected subcutaneously with CsA (5, 10 and 50 mg.kg-1.d-1) for three weeks; the kin was analyzed by la immunohistochemistry and by electron microscopy. Epidermal immunolabeled cells were 15±3.5 (mean ± SEM) per 100 basal keratinocytes in untreated controls and 8.75±1.3, 4.75±1.0 and 1.7±1.2 upon increasing doses of CsA (p