Transcriptional regulation of the bcl-x gene encoding the anti-apoptotic Bcl-xL protein by Ets, Rel/NFkB, STAT and AP1 transcription factor families

• Sevilla, L. ^[1] ; Zaldumbide, A. ^[1] ; Pognonec, P. ^[1] ; Boulukos, K.E. ^[1]
  1. [1] Institute of Signalisation, Developmental Biology and Cancer, Centre de Biochimie, Universite de Nice, Faculte des Sciences, Nice, France
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 16, Nº. 2, 2001, págs. 595-601
• Idioma: inglés
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• Resumen

  • Transcription factors play an essential role in determining the fate of a cell by affecting the expression of target genes involved in proliferation , in differentiation and in programmed cell death. Under certain conditions, some of these factors are capable of deregulating expression of genes involved in the cell cycle and/or in programmed cell death resulting in uncontrolled proliferation of the cell. The focus of this review is on the transcriptional regulation of the bel-x gene encoding the anti-apoptotic BcI-xL protein. Since 1999, everal papers have implicated members of the Ets, Rel/NFKB, STAT and AP-l families as transcription factors regulating bel-x expression. A specific emphasis of these different transcription factor families on bel-x regulation in hematopoietic cells is discus ed.