Evidence that dendritic cells infiltrate atherosclerotic lesions in apolipoprotein E-deficient mice

• Bobryshev, Y.V. ^[2] ; Taksir, T. ^[1] ; Lord, R. S. A. ^[3] ; Freeman, M. W. ^[1]
  1. [1] Massachusetts General Hospital

     Massachusetts General Hospital

     City of Boston, Estados Unidos

     
  2. [2] Surgical Professorial Unit, University of New South Wales, SI. Vincent's Hospital, Sydney, Australia, and 2Lipid Metabolism Unit, Harvard Medical School, Massachusetts General Hospital, Boston, USA
  3. [3] Surgical Professorial Unit, University of New South Wales, SI. Vincent's Hospital, Sydney, Australia

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 16, Nº. 3, 2001, págs. 801-808
• Idioma: inglés
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  • Earlier we reported that atherosclerotic lesions of apoE-deficient mice contained cells which stained positively with anti-S-100 antibody and that cells exhibiting the ultrastructural features of dendritic cells were present in the aortic lesions. These observations suggested that dendritic cells might be involved in mouse at herosclerosis. By employing DEC-205 and MIDC-8 antibodies specific for dendritic cells, the present study has established that dendritic cells indeed accumulate in atherosclerotic lesions of apoE-deficient mice. Finding dendritic cells infiltrating athero clerotic lesions in apoE-deficient mice offers the possibility of investigating the migratory routes of dendritic ce\1s and their involvement in T-ce\1 activation.