The immunohistochemical expression of stress-response protein (srp) 60 in human brain tumours: Relationship of srp 60 to the other five srps, proliferating cell nuclear antigen and p53 protein

• Kato, S. ^[1] ; Kato, Massuo J. ^[2] ; Hirano, A. ^[3] ; Takikawa, M. ^[1] ; Ohama, E. ^[1]
  1. [1] Institute of Neurological Sciences

     Institute of Neurological Sciences

     Mangone, Italia

     
  2. [2] Tottori University

     Tottori University

     Japón

     
  3. [3] Albert Einstein College of Medicine

     Albert Einstein College of Medicine

     Estados Unidos

     

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 16, Nº. 3, 2001, págs. 809-820
• Idioma: inglés
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  • This study analyzed the expression of stressresponse (heat-shock) protein 60 (srp 60) in a series of 158 human brain tumours. Immun ohi tochemical procedures were employed; cells of the human cervical cancer line HeLa S3 exposed to hyperosmolar stress served as positive controls. Deposit of reaction products were found in the cytoplasm. Approximately half of the glioblastomas multiforme (17/31), breast carcinoma metastases (6/10), and lung carcinoma metastases (5/11) as well as about one-third of the astrocytomas (5/13) and meningiomas (8/23) had tumour cell that expressed srp 60. A positive reaction for srp 60 was also seen in some medulloblastomas (2/ 16), primitive neuroectodermal tumours (PNETs) (2/ 11), schwannomas (2/21), and pituitary adenomas (217), but no positive reactions were observed with oligodendrogliomas and ependymomas.

    Compared with srp 60-negative tumours, srp 60-positive tumour coexpressed one or more stre s-related proteins, among which rp 90, srp 72, srp 27, alphaB-crystallin and ubiquitin occurred with higher frequencies; a high correlation between srp 60 and the other five srps (0.88 - 0.97, p