Resumen de Consumption of Fructose Rich Industrialized Beverages in Patients with Biopsy-Proven Non-alcoholic Fatty Liver Disease: a Cross-Sectional Study
Geyza Nogueira de Almeida Armiliato, Mateus Jorge Nardelli, Sílvia Marinho Ferolla, Érika Cristina Lima, Quelson Coelho Lisboa, Paula Vieira Teixeira Vidigal, Teresa Cristina de Abreu Ferrari, Claudia Alves Couto
Introduction: Non-alcoholic fatty liver disease (NAFLD)ranges from simple steatosis to nonalcoholic steatohepatitis(NASH) and liver fibrosis. Recently, consumption of high fruc-tose corn syrup (HFCS) has been associated with NAFLD de-velopment. Objective: The aim of this study was to investigate the re-lationship between consumption of HFCS and NAFLD associ-ated metabolic factors and disease progression. Methods: This cross-sectional study included 51 patientswith biopsy-proven NAFLD who underwent biochemical tests,anthropometrical assessment and full-day dietary evaluationincluding industrialized beverages quantification. Results: Individuals were 80% female, with 54 ± 12 yearsold, 96% with central obesity, 75% with insulin resistance ordiabetes mellitus and were separated according to industrial-ized beverage intake: < 7 and ≥ 7 coups/week (i.e., daily).Daily consumption of HFCS was associated with obesity (P =0.04), hypertriglyceridemia (P = 0.05), higher serum triglyc-erides (P = 0.03) and VLDL (P = 0.01). There was a signifi-cant correlation (R = 0.29; P = 0.04) between consumptionof industrialized beverages and increased serum triglycerides.We found no association between daily HFCS intake andNASH diagnosis or presence of fibrosis.
Conclusion: Excessive consumption of HFCS in industrializedbeverages was associated with obesity, hypertriglyceridemiaand high levels of blood triglycerides in patients with NAFLD.
