Resumen de Histone Deacetylase 3 Protein: towards a unified structural-functional approach
The inhibition procedure of histone deacetylase 3 (HDAC3) has been intensively studied because of the important roles that this protein plays in the regulation of gene expression, epigenetic repression, transcription, replication, recombination, and repair. HDAC3 is required for the proper balance of acetylation/deacetylation dynamics of genes, and it is involved in cell growth and the apoptotic process of all cell types via the regulation of pro-apoptotic genes. The overexpression of HDAC3 protein might lead to uncontrolled cell proliferation and inhibition of both differentiation and apoptosis. Therefore, downregulating HDAC3 seems to be critical for the treatment of a wide range of diseases, with special emphasis on cancer. In the present work, the main structural-functional characteristics of HDAC3 are exhaustively described. A first feature set consisted of the nucleotide sequence and from the primary to the quaternary structures of HDAC3. The knowledge of the conformations and coupling of this protein in different complexes determines the functionality of HDAC3. Therefore, a second feature set was defined to elucidate the interactions, ligands, homologies, and functions of HDAC3. Summarizing most of the characteristics of HDAC3 into a single structural-functional approach, including histone deacetylase inhibitors (HDIs) to regulate its overexpression as a possible practical application, is the key contribution of this review.
