Morbidity involving the hallucinogenic designer amines MDA and 2C-I
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[1] University of California System
University of California System
Estados Unidos
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- Localización: Journal of forensic sciences, ISSN-e 1556-4029, ISSN 0022-1198, Vol. 54, Nº. 6, 2009, págs. 1485-1487
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
A case is presented of a 39-year-old woman who suffered severe debilitation because of a hemorrhagic stroke in the context ofsubstance abuse. The patient presented to the emergency room with rapidly diminishing mental status, hypertension, and vasoconstriction; her friendsprovided a history of ingestion of cocaine, 3,4-methylenedioxymethamphetamine (MDMA), and 2C-I, a novel designer amine. A multi-targeted LC-MS ⁄ MS method for sympathomimetic amines and related drugs in urine detected and quantified 2C-I and MDA, while ruling out MDMA. The causeof the stroke was determined to be an underlying cerebrovascular abnormality called Moyamoya, secondary to substance abuse. In clinical laborato-ries, gas chromatography–mass spectrometry or liquid chromatography–tandem mass spectrometry (LC-MS/MS) confirmation of a positive amphet-amine immunoassay is usually directed only towards amphetamine, methamphetamine, MDMA and MDA. This report demonstrates the utility oftesting for a wider menu of compounds using LC-MS ⁄ MS in order to better characterize the prevalence and toxicities of novel amines such as 2C-I
