Resumen de Ran in the spindle checkpoint: a new function for a versatile GTPase

Hoi-Yeung Li, Yixian Zheng, Kan Cao

• The small GTPase Ran has a well-established role in nucleocytoplasmic trafficking. In recent years, the repertoire of Ran has expanded to include regulation of spindle assembly, formation of the nuclear envelope and DNA replication. Now, new studies further extend the role of Ran to regulating the spindle checkpoint during mitosis.