Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

• Autores: Chris M. McGinley, Wilfred A. van der Donk
• Localización: Chemical communications, ISSN 1359-7345, Nº. 23, 2003, págs. 2843-2846
• Idioma: inglés
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• Resumen

  • The oxidation of polyunsaturated fatty acids such as arachidonic and linoleic acid initiates a plethora of cell signaling pathways in animals and plants. The chemistry of the enzymatic oxidation has been investigated for several enzymes, most notably prostaglandin synthase and the lipoxygenases, revealing many surprises and impressive examples of enzymatic control of hydrogen atom abstraction and subsequent oxygenation