Evaluation of patients with primary immunodeficiency associated with Bacille Calmette-Guerin (BCG)-vaccine-derived complications

• M. Sohani ^[3] ; S. Habibi ^[3] ; S. Delavari ^[3] ; S. Shahkarami ^[3] ; Reza Yazdani ^[3] ; P. Shirmast ^[3] ; F. Nazari ^[3] ; T. Moeini Shad ^[3] ; S. Mamishi ^[1] ; G. Azizi ^[4] ; A.U. Anka ^[5] ; G. Hassanpour ^[1] ; A. Kalantari ^[1] ; M. Shariat ^[1] ; A. Shafiei ^[1] ; H. Abolhassani ^[2] ; A. Aghamohammadi ^[3]
  1. [1] Tehran University of Medical Sciences

     Tehran University of Medical Sciences

     Irán

     
  2. [2] Iran University of Medical Sciences

     Iran University of Medical Sciences

     Irán

     
  3. [3] Tehran University of Medical Science, Irán
  4. [4] Alborz University of Medical Sciences, Irán
  5. [5] Ahmadu Bello University, Irán

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 48, Nº. 6, 2020, págs. 729-737
• Idioma: inglés
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• Resumen

  • Background Bacille Calmette-Guerin (BCG) vaccination has a great impact on the prevention of severe complications of tuberculosis. However, in patients with primary immunodeficiencies (PID), it can lead to severe complications such as severe combined immunodeficiency, chronic granulomatous disease, and Mendelian susceptibility to mycobacterial disease. This study highlights the demographics, clinical complications and laboratory parameters among PID patients associated with BCG vaccination side effects.

    Methods One hundred and thirty-seven PID patients with BCGosis were evaluated in this study, based on the complications following BCG vaccination.

    Results The mean age of the patients with BCG complications at the time of the first visit was five years. The within-group comparison of patients showed a highly significant incidence of pneumonia and hepatomegaly in severe combined immunodeficiency patients. Furthermore, the immunologic data showed an increase in the overall rates of lymphocytes such as CD3+, CD4+ and CD8 + T cells in Mendelian susceptibility to mycobacterial disease patients. The level of immunoglobulins has also increased in chronic granulomatous disease patients.

    Conclusion The high rate of undiagnosed PIDs predisposes individuals to a high risk of severe side effects as a result of BCG vaccination, as well as infants that are less than one month of age. Therefore, there is a need for early screening and diagnosis of PIDs before exposing unknown PID status patients to BCG vaccination. The benefits of screening and early diagnosis of PID cannot be overemphasized, especially in patients with a previous family history of immunodeficiency.