Despite cutaneous squamous cell carcinoma (cSCC) being the second most common skin cancer,1 our knowledge of the epidemiologic characteristics of cSCC is suboptimal. Dermatologists see patients with cSCC regularly in clinic, but we do not have high-quality information on the basic cancer statistics that are the bread and butter of oncology research and clinical care. For example, the publicly accessible Surveillance, Epidemiology, and End Results (SEER) Cancer Statistics Review2 contains 30 tables and 7 figures on incidence and mortality for lung cancer in the United States, with age and sex breakdowns, going back to 1975. However, cSCC is nowhere to be found. In many countries, such as the US, cSCC is not included in cancer registries, which has long been recognized as a barrier to understanding this malignant neoplasm.
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