Farnesoid X receptor: a potential therapeutic target in multiple organs

• Chao Zhang ^[1] ; Zixuan Wang ^[1] ; Qingqing Feng ^[1] ; Wei-Dong Chen ^[2] ; Yan-Dong Wang ^[1]
  1. [1] Beijing University of Chemical Technology

     Beijing University of Chemical Technology

     China

     
  2. [2] Inner Mongolia Medical University
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 35, Nº. 12, 2020, págs. 1403-1414
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Farnesoid X receptor (FXR), a member of the nuclear receptor family, is a common receptor found in the intestine and liver, and helps to maintain systemic metabolic homeostasis through regulating bile acid, glucose, lipid metabolism, and energy homeostatsis. In addition, FXR regulates the functions of various organs, such as liver, intestine, kidney, breast, pancreas, cardiovascular system and brain. FXR also plays a key role in regulation of gut-microbiota through mediating the various signaling pathways. Accordingly, FXR has become an attractive therapeutic target in a variety of diseases. This review combines classical and recent research reports to introduce the basic information about FXR and its important roles in various organs of the body