Resumen de Enzyme Free Energy Diagrams: Enzyme–Substrate Binding Is Always Spontaneous
In at least two papers published in this Journal, enzyme free energy diagrams were presented showing enzyme–substrate binding to be nonspontaneous. I present here several different approaches showing that enzyme–substrate binding is always spontaneous, and the y-axis of the reaction progress diagrams presented previously is in fact standard enthalpy (H°), and not free energy.
