Fecal microbiota transplantation in the intestinal decolonization of carbapenamase-producing enterobacteriaceae

• João Carlos Silva ^[2] ; Ana Ponte ^[2] ; Margarida Mota ^[2] ; Rolando Pinho ^[2] ; Nuno Vieira ^[2] ; Rosa Oliveira ^[2] ; Nelson Mota-Carvalho ^[1] ; Ana Catarina Gomes ^[2] ; Edgar Afecto ^[2] ; João Carvalho ^[2]
  1. [1] Universidade Católica Portuguesa

     Universidade Católica Portuguesa

     Socorro, Portugal

     
  2. [2] Centro Hospitalar Vila Nova de Gaia/Espinho. Vila Nova de Gaia, Porto. Portugal
• Localización: Revista Española de Enfermedades Digestivas, ISSN-e 2340-4167, ISSN 1130-0108, Vol. 112, Nº. 12, 2020, págs. 925-928
• Idioma: inglés
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• Resumen

  • Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.